Climb the 251 steps up the spectacular Leaning Tower or Campanile (bell tower) on the Field of Miracles in Pisa. The 56-meter-high tower took almost 200 years to build, but it was already leaning when it was unveiled in 1372. Access is limited to 45 people at a time. Book online in advance to save a space — many tourists flock here.
In Florence, you can't miss the Santa Maria del Fiore cathedral, more commonly called the Duomo in honor of its red-tiled cupola, or dome. The city's most iconic landmark, dating back to 1296, the Duomo's pink, white and green marble facade is a must-take photo. Head inside to admire the 44 stained-glass windows and Vasari's magnificent fresco of the Last Judgment.