1 Night Southern Caribbean Cruise on Serenade of the Seas from Colón, Panama Colon, Panama Fortifications
The 1 Night Southern Caribbean Cruise from Colón, Panama visits Cartagena, Colombia. Explore our cruise itineraries and choose from a variety of rooms depending on your needs and budget. Start planning your next cruise vacation by selecting a destination and departure port.
Royal Caribbean Cruises
Priced from: $103.11 per person 1 sailing dates available
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1 Night Southern Caribbean Cruise
Itinerary Overview
Explore Serenade of the Seas
Day 1 - Colón, Panama
Day 2 - Cartagena, Colombia
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Colon, Panama Fortifications
Fortifications on the Caribbean Side of Panama in Colon
This is your

1 Night Southern Caribbean Cruise

Explore This Itinerary
Leaving from
Colón, Panama
Onboard
Serenade of the Seas
Day Port
1
Colón, Panama
Departs at 4:00 PM
2
Cartagena, Colombia
Arrives at 9:00 AM
*Port sequence may vary by sailing date.
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Taxes & fees included.*

Your ship Serenade of the Seas

Your ship
Serenade of the Seas
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Serenade of the Seas Cruise Ship, Side View, European and Caribbean Destinations
Side View of Serenade of the Seas Cruise Visiting Bermuda, Norwegian Fjords, Scandinavia
Get to know
Serenade of the Seas
From poolside movie nights and jaw dropping entertainment, to game changing flavors prepared to please your palate, all paths lead to discovery onboard Serenade of the Seas®.

BANISH BOREDOM FOR GOOD

Panoramic vistas aren't all you'll find on this ship. Get active on the Rock Climbing Wall or with a game of mini golf. Head to Vitality℠ at Sea Spa and Fitness Center to break a sweat or indulge in some "me time." And a giant poolside movie screen means plenty of opportunities to unwind outside.

NEXT LEVEL NOSHING

Craving something delicious? You've come to the right place. Serenade of the Seas® is brimming with far out flavors, like tantalizing Tuscan fare at Giovanni's Table, steaks seared to perfection at Chop's Grille℠ and five-courses of incredible at Chef's Table. For the perfect glass of wine, Vintages has your back.

PEAK PERFORMANCES

As the day winds down, the night heats up with dazzling productions by world-class performers. Whether it's all the hits from Broadway and the Big Screen in Stage to Screen, or remixed classics in Vibeology, you're definitely in for a show.

Day 1: Colón, Panama

Day 1
Colón
Panama
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Colon, Panama Sloth Hanging On Tree
Wild two-toed sloth hanging on tree in Colon Island, Bocas del Toro, Panama.
Things to do in
Colón
Departs at 4:00 PM
Home to the Panama Canal's Atlantic Ocean entryway, Colón is the second-largest city in Panama. Start your adventure at the Gatun locks, where you can watch ships being raised by water lifts to the higher elevation of the canal. Then, visit the Portobelo Natural Park and take in the beauty of its 16th century forts. Or head to the beach at Playa Maria Chiquita for clear Caribbean Sea waters and white sands. Cruise to Colón, Panama and check out Portobelo National Park, where you can see 17th-century Fort San Lorenzo or go bird-watching along the Achiote Trail in San Lorenzo Protected Forest. Or take the one-hour trek to Panama City, the Caribbean's urban heartbeat.
Colon, Panama Canal
The second lock of the Panama canal from the Pacific ocean

Lock in the Wonder

Experience the Panama Canal in all its engineered glory as you witness ships being lifted in the Gatun locks to enter Gatun Lake. Ships then traverse through the lake and exit the canal on the Pacific Ocean side, going down again in the Miraflores locks.
Insider tip
Only in Panama can you watch the sun rise on the Pacific Ocean and set on the Atlantic Ocean. All it takes is a 50-mile taxi ride from one side of the country to the other.
Colon, Panama, San Lorenzo Fort
The San Lorenzo fortifications in Portobelo National Park in Colon, Panama

Naturally Fortified

Head to the Portobelo National Park, a UNESCO World Heritage Site, and find yourself surrounded by historic fortifications like the ruins of San Lorenzo Castle and Fort. Don't miss San Lorenzo Protected Forest, which houses many hiking trails and marine flora and fauna, like mangroves and sea turtles.
Colon, Panama Cathedral
The Panama Cathedral in Colon

The Beat of the City

Drive for just an hour and find arguably the most visually appealing city in Central America: metropolitan Panama City. Cruise to Colón and walk by impressive skyscrapers like the Vitri Tower, feed your artistic side with a visit to BioMuseo museum, and shop for souvenirs in the historic streets of Panama Viejo.
Colon, Panama Empanadas
Young woman holding in hands wicker basket with freshly baked empanadas

Local Cuisine

Seafood in its many forms is the staple cuisine of Colón. Sample shrimp and coconut rice or white fish ceviche marinated in lime and habanero. Not feeling like fish? Seek out golden-brown empanadas stuffed with meat and cheese or sancocho, a hearty chicken stew with corn, squash and herbs. Finish your meal with raspados, the local dessert of grated ice sweetened with condensed milk.
Colon, Panama Hats
Panama Hats sold in Colon, Panama

Shopping

The Colón Free Zone is one of the biggest duty-free markets in the world. Head here to find wholesale stores selling everything from clothes to shoes and jewelry during your Colón cruise. If you're heading to Panama City, don't miss out on the shopping there. Shops like Karavan, Beermarkt and Papiro y Yo selling indigenous art, local beer and the ever-popular Panama hats.

Day 2: Cartagena, Colombia

Day 2
Cartagena
Colombia
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Cartagena, Colombia, Church of St. Peter Claver
Church of St. Peter Claver in Cartagena, Colombia
Things to do in
Cartagena
Arrives at 9:00 AM
Cartagena, Colombia, is a dazzling blend of history, culture, and Caribbean beauty. As one of South America’s most captivating cruise ports, it welcomes travelers with colorful colonial streets, sunlit plazas, and the scent of ocean air. Cruises to Cartagena, Colombia Port open the door to centuries-old fortresses, vibrant local markets, and white-sand beaches. Wander through the UNESCO-listed Old Town, where cobblestone lanes lead to flower-draped balconies and lively cafés. Take in the sweeping views from Castillo San Felipe de Barajas, a fortress that once guarded the city from pirates, or relax on the nearby Rosario Islands, known for turquoise waters and coral reefs. From rich Afro-Caribbean rhythms to fresh seafood served beachside, Cartagena’s charm lingers long after you sail away.
Cartagena, Colombia, Street view
Buildings with balconies lining a street in Cartagena, Colombia

Old Town Magic

Step inside Cartagena’s walled city, a UNESCO World Heritage Site where cobblestone streets, colorful colonial homes, and lively plazas capture centuries of history and charm.
Insider tip
Discover the natural benefits of a mud bath at Volcan de Lodo el Totumo — an active mud volcano 30 miles outside of Cartagena.
Cartagena, Colombia, Isla de Rosario
Small boats anchored close to shore at Islas de Roasario, Colombia

Fortress Views

Climb Castillo San Felipe de Barajas, a massive fortress built to protect the city from pirates. Walk through its tunnels and enjoy sweeping views of the harbor.
Cartagena, Colombia, Market
An outdoor market under a covered walkway in Cartagena, Colombia

Island Escape

Sail to the Rosario Islands, where turquoise waters and coral reefs invite you to snorkel, swim, and unwind on pristine white sands.
Cartagena, Colombia, Arepas rellenas
Two arepas rellenas filled with shredded beef

Local Cuisine

Cartagena’s food reflects its coastal roots with vibrant flavors and local freshness. Enjoy fried plantains, coconut rice, and shrimp ceviche served beachside. From casual street stalls to elegant restaurants, the city’s cuisine celebrates its Caribbean heart.
Cartagena, Colombia, Traditional hats for sale
Traditional hats for sale in Cartagena, Colombia

Shopping

Shopping in Cartagena is as lively as its streets. Visit Las Bóvedas market for handmade crafts and woven bags, or browse the boutiques in the Old Town for fine emerald jewelry and Colombian fashion.

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