By Sherri Eisenberg | Published on August 5, 2025 | Updated: April 15, 2026
The blue sea sparkles in the sun, the taste of freshly caught seafood lingers on your tongue and your days are filled with visiting ancient architectural wonders. No, it's not a dream; you're on an unforgettable Mediterranean Sea cruise. On many of the best cruises to The Mediterranean, you'll likely see more than one country, offering you the chance to explore different cultures with ease and comfort. Best of all, you can take Mediterranean cruises from Barcelona, Rome, Venice Athens and more. Read on for a list of the top itineraries. This is where to go and what to see when you embark on the top Mediterranean cruises for your next holiday.
If there were ever places that combine culture and romance to perfection, it's Italy and France, and the best cruises to the Mediterranean will bring you everywhere you want to go in these beautiful countries.
Italy's beauty is unrivaled. Stroll through cobblestone streets in Florence until you're face-to-face with the Duomo, a stunningly beautiful burnt orange dome on top of a church.
A quick ride from there will bring you to the Tuscan hills where you can sip on some of the best wines in the world. Or take to the canals in Venice, riding a gondola past the Doge's Palace and under Rialto Bridge. In Rome, you can visit Vatican City or the Colosseum before heading to the Trastevere neighborhood to sample classic Roman pasta dishes like carbonara. Eating in Italy is, of course, one of life's true pleasures.
If you're interested in more of a sunny holiday, the Amalfi Coast provides the sun-dappled summer of your dreams. Here, you can hike Mount Vesuvius, indulge in some of the world's best pizza in Naples, sip on limoncello in Sorrento and take in the views from the cliffside streets of Positano. As you sail on The Mediterranean Sea, you’ll cruise past the active volcano, Mount Etna.
On sailings to the nearby French Riviera, you'll discover just how chic a sun-drenched destination can be. In Nice, take a stroll down the Promenade des Anglais or wander through the ancient shopping streets, finding yourself at a market filled with artisanal olive oil soap, sacks of herbs de Provence and lavender sachets.
In Cannes, walk along La Croisette or head over to St. Tropez and settle into a beach club. You can use Marseille as a jumping-off point to explore Provence's gorgeous little villages, or take the time to get to know the city itself. And when you're feeling hungry, you'll be spoiled for choice. Dig into ratatouille or a heaping bowl of bouillabaisse and take the time to linger and savor your wine. Sounds delicious, right?
Corsica is a French island located just off the south of France, and it’s the former home of Napoleon Bonaparte. He grew up here and was baptized in the Notre Dame Cathedral right in town, and his family home now serves as a museum.
To take in the island's natural beauty, visit the dramatic red-rock cliffs of Calanques de Piana. If you'd rather take a stroll through the old town, you can visit Place Foch in Ajaccio, where you'll fall in love with the charming rainbow-colored buildings. Spend the rest of your day pairing Corsican wine with amazing local cheeses and cured meats. If you see “civet de sanglier” on a menu, order it: This delectable wild boar stew is the most popular dish on the island.
If you're wondering, "What is the best month to cruise the Mediterranean?" and you're trying to avoid crowds, May, September and October are ideal. If you want a sunny, beachy experience, it's worth it to face the summer throngs.
This is a time you can stretch out on one of the Mediterranean's best sandy strands all afternoon before wandering ancient cobblestone streets in handmade leather sandals with gelato in hand. That’s the best time to visit the French Riviera, the Amalfi Coast and islands like Sardinia and Capri.
Greece is studded with amazing destinations built around the water, each with its own style and history. A cruise around the Greek Isles could be one of the best cruises for couples and families who like to enjoy a little bit of everything. Mykonos is known for its extravagant parties, and you can join in the fun at the famous Scorpios beach club.
Or head to Santorini and wander through the streets lined with whitewashed homes topped with turquoise domes. A trip to Milos will bring you face-to-face with massive white cliffs that will make you feel as if you're on the moon. If it's history you're after, make a stop in Athens and visit the Acropolis to feel like you’re stepping back in time.
No matter where you stop on your epic Greek vacation, you can feast on some of the finest seafood in the world. You can also indulge in local favorites such as gyros, souvlaki and honey-laden baklava. Make sure to plan to pick up extra. I always buy Greek pastries to bring home, and then end up eating the sweets on my balcony as we sail away instead.
Regardless of which islands you find yourself visiting, these coastal beauties are some of the best spots to visit in Greece.
Think of a Western Mediterranean cruise as the sampler platter of travel to this region. It allows you to see the highlights of several countries, and you only have to unpack once. You can choose an option that combines the most popular ports in Spain (Barcelona and Palma de Mallorca), France (Nice and Marseille) and Italy (such as Rome, Naples and Florence), for example.
Many of these sailings start or end in Barcelona. While not technically part of the Mediterranean, parts of Spain (including Barcelona) can be found on the Balearic Sea, which flows right into the Mediterranean. The coastal ports are some of the most exciting places to visit in this beautiful country.
Barcelona is a colorful city with magnificent architectural sights by famed architect Antoni Gaudí, such as the Sagrada Familía Basilica and the whimsical gardens of Park Güell. This is one of my favorite parks in Europe. You'll also quickly see that Barcelona is home to some of the best Mediterranean dishes for foodies, which is just one reason this is a highlight on the best Mediterranean cruises for couples.
Find yourself wandering down the aisles of La Boqueria, a world-famous food market, where you can pick up some of the freshest produce imaginable and sit down for a bite of tapas. Or, head to the beach and enjoy the sunshine before ordering some seafood by the sea.
When you want extra time in this fabulous city, consider booking a Mediterranean cruise from Barcelona so you can spend a few days here before setting sail. Keep in mind that Spain is rich with exciting ports, and Barcelona is just one of them. If you have time in your travel itinerary, head to Palma de Mallorca for even more fabulous beach time and exciting nightlife.
Another sampler option includes stops at the highlights of Croatia (Dubrovnik and Split), a variety of ports in Italy (Venice, Trieste, Salerno and Rome) and Kotor in Montenegro. While Croatia hasn’t always been as popular as some of its neighbors, this destination is a must-see on some of the best cruises to the Mediterranean.
Known as the backdrop of Game of Thrones, which was partially filmed here, Croatia’s beauty often takes cruisers by surprise. From the walled city of Dubrovnik to the palace of Split to the ancient Roman ruins of Istria, there is much history to discover in Croatia. The true wonder is the natural beauty you'll find throughout the country.
Visit Krka to see cascading waterfalls, or travel to the Plitvice Lakes National Park to see towering mountains. Island hop the Dalmatian Coast, making stops at the small, quaint villages and stunning beaches along the way.
Croatian cuisine tells a mouthwatering story of its local culture and history. Cooked on wood-fired grills, drizzled with olive oil and cooked slowly, the food is insanely delicious and prepared with pride. Don't miss out on “crni rižot,” a black risotto that's made with squid ink. Or try “gregada,” a fish stew filled with scorpion fish or grouper.
If it’s a quieter cruise destination you’re craving, tiny Montenegro delivers. Most first-time visitors explore Kotor, which is home to one of the most well-preserved medieval towns in the area. Explore the Old City, where you can see huge forts, ornate churches and beautiful museums — all of which make it one of the highlights of the best Mediterranean cruises for families.
If you want to stretch your legs, hike to the top of the Fortifications of Kotor (a UNESCO World Heritage Site) for some of the most amazing panoramic views you've ever seen. When you look out at the horizon, you'll see sapphire waters, lush green landscape and towering mountains.
You'll be hungry after your hike, and you will have earned a feast. Consider “buzara,” which is shellfish cooked in red or white sauce. If you’re not a fan of seafood, indulge in “ispod sača,” which is made of veal, lamb or goat that's slow-roasted until tender.
Another sampler cruise, these itineraries tend to sail out of Athens and dock in some of Greece's top islands (Santorini, Rhodes), a couple of Turkish seaside ports (Kusadasi, Bodrum) and Limassol in Cyprus. Turkey's ports are rich with history. Kusadasi is most known for its well-preserved ruins at the excavation of Ephesus, where you can see town squares and public baths. Nearby Bodrum is home to a medieval fortress and a castle, too.
Travelers to Limassol, Cyprus's main cruise port, often head right to a beach. It's a smart move. You can soak up the sun at Akti Olympion Beach, where you can rent an umbrella-topped lounge chair or try your hand at windsurfing or parasailing. That’s all before dusting off the sand to visit Kourion, a UNESCO heritage site that's home to a restored Greek-Roman theater that’s still in use today.
When you find yourself hungry and needing a culinary pick-me-up, look for freshly caught seafood, including clams and mussels.
Cruises to Italy, Croatia and Malta blend the highlights of Italy — Rome, Naples, Sicily and Venice — with a couple of Croatian ports (Dubrovnik and Split) and the novelty of Valletta, Malta. Ever wanted to see Malta in particular? This is your chance!
This tiny island nation has a walled city with watchtowers along the coast that date all the way back to the 1500s, and were created by the Roman Catholic church's Knights of St. John to defend Malta against the Ottomans. Today, you'll find museums, grand palaces and churches, including the baroque St. John's Co-Cathedral. Here, you'll find Caravaggio's seminal work, "The Beheading of Saint John the Baptist," on display for the public in the oratory.
If you, like me, remember this piece from art history class (and the biblical story of the grudge that inspired the beheading), you'll be wowed by the magnitude of this artwork. After getting your fill of art and history, grab a gelato from Amorina in Valletta. I'm partial to the blood orange, pistachio and orange blossom flavors as they celebrate the bounty of the Mediterranean.
A Mediterranean cruise offers the perfect balance of discovery and indulgence. From Italy’s timeless landmarks to Greece’s postcard-perfect islands and France’s dazzling coastline, every stop reveals a new flavor of history, culture and beauty.
With Royal Caribbean, you can explore multiple countries in comfort, savor world-class dining and return each night to breathtaking sea views. Lovers of ancient ruins, charming seaside towns or golden beaches: The Mediterranean delivers it all in one unforgettable journey. Seamlessly blend adventure, relaxation and luxury in one trip and enjoy the ultimate vacation experience.